Synthesis of Iron-Binding Oligonucleotides and Their Reactions With Single-Stranded DNA
| Autor: | Kady, Ismail O., Groves, John T. |
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| Zdroj: | ETSU Faculty Works. |
| Druh dokumentu: | Text |
| DOI: | 10.1016/S0960-894X(00)80350-9 |
| Popis: | Two 12-base oligonucleotides were synthesized and modified by attaching metal-binding ligands (2,6-pyridinedicarboxylate and 2,2′-dipicolylamine) to their 5′-ends. When hybridized to a 135-base single stranded DNA, in the presence of Fe2+, O2, and a reducing agent, these obligonucleotides cleaved the complementary DNA chain with unique and high base-sequence specificities. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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