| Autor: |
Bauer, Andrea, Thyssen, Jacob P., Buhl, Timo, Svane Nielsen, Thor Schütt, Larsen, Lotte Seiding, Østerskov, Anne Birk, Agner, Tove |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Druh dokumentu: |
Článek |
| ISSN: |
1600-0536 |
| DOI: |
10.1111/cod.14303 |
| Popis: |
Background: Measuring patient-reported outcomes is crucial to fully capture the burden of chronic hand eczema (CHE). - Objectives: To assess the effect of delgocitinib cream on itch, pain and nine additional key signs and symptoms reported by patients with CHE using the Hand Eczema Symptom Diary (HESD). - Methods: In a double-blind, phase IIb dose-ranging trial (NCT03683719), 258 adults with mild to severe CHE were randomized to delgocitinib cream 1, 3, 8 or 20 mg/g or cream vehicle twice daily for 16 weeks. Patients assessed 11 signs and symptoms of CHE daily through the HESD using an 11-point numeric rating scale; this was an exploratory endpoint. - Results: Delgocitinib cream 20 mg/g was associated with an early and sustained reduction in itch and pain, along with clinically relevant reductions of ≥4 points from baseline to Week 16 in 48.4% and 63.6% of patients, respectively (17.9% and 5.9% with cream vehicle). There were improvements versus cream vehicle in all assessed CHE signs and symptoms (20 mg/g, p |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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