| Autor: |
Wittenstein, Jakob, Scharffenberg, Martin, Yang, Xiuli, Bluth, Thomas, Kiss, Thomas, Schultz, Marcus J., Rocco, Patricia R. M., Pelosi, Paolo, De Abreu, Marcelo Gama, Huhle, Robert |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Druh dokumentu: |
Článek |
| ISSN: |
1664-042X |
| DOI: |
10.3389/fphys.2023.1204531 |
| Popis: |
Background: Global and regional transpulmonary pressure (PL) during one-lung ventilation (OLV) is poorly characterized. We hypothesized that global and regional PL and driving PL (ΔPL) increase during protective low tidal volume OLV compared to two-lung ventilation (TLV), and vary with body position. Methods: In sixteen anesthetized juvenile pigs, intra-pleural pressure sensors were placed in ventral, dorsal, and caudal zones of the left hemithorax by video-assisted thoracoscopy. A right thoracotomy was performed and lipopolysaccharide administered intravenously to mimic the inflammatory response due to thoracic surgery. Animals were ventilated in a volume-controlled mode with a tidal volume (VT) of 6 mL kg⁻¹ during TLV and of 5 mL kg⁻¹ during OLV and a positive end-expiratory pressure (PEEP) of 5 cmH₂O. Global and local transpulmonary pressures were calculated. Lung instability was defined as end-expiratory PL |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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