| Autor: |
Maith, Oliver, Baladron, Javier, Einhäuser, Wolfgang, Hamker, Fred H. |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Druh dokumentu: |
Článek |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2023.106599 |
| Popis: |
Humans can quickly adapt their behavior to changes in the environment. Classical reversal learning tasks mainly measure how well participants can disengage from a previously successful behavior but not how alternative responses are explored. Here, we propose a novel 5-choice reversal learning task with alternating position-reward contingencies to study exploration behavior after a reversal. We compare human exploratory saccade behavior with a prediction obtained from a neuro-computational model of the basal ganglia. A new synaptic plasticity rule for learning the connectivity between the subthalamic nucleus (STN) and external globus pallidus (GPe) results in exploration biases to previously rewarded positions. The model simulations and human data both show that during experimental experience exploration becomes limited to only those positions that have been rewarded in the past. Our study demonstrates how quite complex behavior may result from a simple sub-circuit within the basal ganglia pathways. |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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