| Autor: |
Alexej, Surov, Schmidt, Stefan A., Prasad, Vikas, Beer, Ambros J., Wienke, Andreas |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Druh dokumentu: |
Článek |
| Popis: |
Background: Hypoxia-inducible factor (HIF)-1a plays a key role in hypoxic adaptation of tumor cells. Overexpression of HIF-1a is associated with tumor aggressiveness and worse prognosis in several malignancies. Presumably, expression of HIF-1a may be reflected by positron emission tomography with 2-deoxy-2 [fluorine-18] fluoro-D-glucose (18F-FDG PET). There are inconsistent data about relationships between FDG PET and HIF-1a. Purpose: To provide evident data about associations between maximum standardized uptake value (SUVmax) and HIF-1a expression in solid tumors. Material and Methods: MEDLINE, SCOPUS, and EMBASE databases were screened for relationships between SUV and HIF-1a up to August 2019. Overall, 21 studies with 1154 patients were identified. The following data were extracted from the literature: authors; year of publication; number of patients; and correlation coefficients. Results: Correlation coefficients between SUVmax and HIF-1a were in the range of 0.51–0.71. The pooled correlation coefficient was 0.27 (95% confidence interval [CI] ¼ 0.14–0.41). Furthermore, correlation coefficients for some tumor entities were calculated. For this sub-analysis, data for primary tumors with >2 reports were included. The calculated correlation coefficients in the analyzed subgroups were as follows: head and neck squamous cell carcinoma: q ¼ 0.25 (95% CI ¼ 0.07–0.42); non-small lung cell cancer: q ¼ 0.27 (95% CI ¼ 0.14–0.67); uterine cervical cancer: q ¼ 0.09 (95% CI ¼ 0.89–0.71); thymic tumors: q ¼ 0.39 (95% CI ¼ 0.04–0.58). Conclusion: SUVmax of FDG PET correlated weakly with expression of HIF-1a both in overall sample and tumor subgroups. Therefore, FDG PET cannot be used for prediction of hypoxia in clinical practice |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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