Polydopamine-mediated long-term elution of the direct thrombin inhibitor bivalirudin from TiO₂ nanotubes for improved vascular biocompatibility
| Autor: | Yang, Zhilu, Zhong, Si, Yang, Ying, Maitz, Manfred F., Li, Xiangyang, Tu, Qiufen, Qi, Pengkai, Zhang, Heng, Qiu, Hua, Wan, Jin, Huang, Nan |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Thrombosis
restenosis vascular stents antithrombosis re-endothelialization nanotubular titanium oxide (TiO₂) system long-term treatment Thrombose Restenose Gefäßstents Antithrombose Reendothelialisierung nanotubulares Titanoxid (TiO₂) System langfristige Behandlung info:eu-repo/classification/ddc/540 ddc:540 info:eu-repo/classification/ddc/530 ddc:530 |
| Druh dokumentu: | Článek |
| ISSN: | 1520-6106 |
| DOI: | 10.1039/c4tb01118j |
| Popis: | Thrombosis and restenosis are two major complications associated with current commercial vascular stents. In situ regeneration of a healthy endothelium has been recognized as a promising strategy to address these issues. Numerous strategies have been explored for this goal. However, in most of the cases, they only focused on enhancing endothelial cell growth, ignoring antithrombotic requirements and the competition between smooth muscle cells (SMCs) and endothelial cells (ECs) for their growth. This resulted in non-satisfying clinical results. In this study, we created a multifunctional surface that meets the need of antithrombosis and re-endothelialization. A nanotubular titanium oxide (TiO₂) system has been developed, which elutes the direct thrombin inhibitor, bivalirudin (BVLD); moreover, polydopamine (PDAM) is used to tailor the surface functionality of TiO₂ nanotubes (NTs) for controlling the elution of BVLD. PDAM-functionalized TiO₂ NTs controls the BVLD for more than two months. BVLD eluted from NTs was bioactive and showed a substantial inhibitory effect on thrombin bioactivity, platelet adhesion and activation. In addition, the BVLD-eluting nanotubular TiO₂ system has high selectivity to enhance human umbilical vein endothelial cell (HUVEC) growth, while it inhibits human umbilical artery smooth muscle cell (HUASMC) proliferation. Our design strategy for the BVLD-eluting nanotubular TiO₂ system creates a favorable microenvironment for durable thromboresistance and the promotion of reendothelialization, and thus it is suitable for the long-term treatment of cardiovascular diseases. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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