Variable versus conventional lung protective mechanical ventilation during open abdominal surgery: study protocol for a randomized controlled trial
Autor: | Spieth, Peter M., Güldner, Andreas, Uhlig, Christopher, Bluth, Thomas, Kiss, Thomas, Schultz, Marcus J., Pelosi, Paolo, Koch, Thea, Gamba de Abreu, Marcelo |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
mechanische Belüftung
variable Berlüftung Vollnarkose Anästhesie Lunge Komplikation TU Dresden Publikationsfonds mechanical ventilation variable ventilation general anesthesia abdominal surgery lung protective ventilation pulmonary complications Technical University Dresden Publication funds info:eu-repo/classification/ddc/610 ddc:610 |
Druh dokumentu: | Článek |
DOI: | 10.1186/1745-6215-15-155 |
Popis: | Background: General anesthesia usually requires mechanical ventilation, which is traditionally accomplished with constant tidal volumes in volume- or pressure-controlled modes. Experimental studies suggest that the use of variable tidal volumes (variable ventilation) recruits lung tissue, improves pulmonary function and reduces systemic inflammatory response. However, it is currently not known whether patients undergoing open abdominal surgery might benefit from intraoperative variable ventilation. Methods/Design: The PROtective VARiable ventilation trial ('PROVAR') is a single center, randomized controlled trial enrolling 50 patients who are planning for open abdominal surgery expected to last longer than 3 hours. PROVAR compares conventional (non-variable) lung protective ventilation (CV) with variable lung protective ventilation (VV) regarding pulmonary function and inflammatory response. The primary endpoint of the study is the forced vital capacity on the first postoperative day. Secondary endpoints include further lung function tests, plasma cytokine levels, spatial distribution of ventilation assessed by means of electrical impedance tomography and postoperative pulmonary complications. Discussion: We hypothesize that VV improves lung function and reduces systemic inflammatory response compared to CV in patients receiving mechanical ventilation during general anesthesia for open abdominal surgery longer than 3 hours. PROVAR is the first randomized controlled trial aiming at intra- and postoperative effects of VV on lung function. This study may help to define the role of VV during general anesthesia requiring mechanical ventilation. |
Databáze: | Networked Digital Library of Theses & Dissertations |
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