Nutrition and Vascular Supply of Retinal Ganglion Cells during Human Development
| Autor: | Rutkowski, Paul, May, Christian Albrecht |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Retinale Ganglienzellen
Sauerstoffversorgung Fetus Erwachsener normale Entwicklung Netzhautkapillaren Choriocapillaris Wasserscheidezonen TU Dresden Publikationsfond retinal ganglion cells oxygen supply fetal adult normal development retinal capillaries choriocapillaris watershed zones publication fund ddc:610 rvk:XA 10000 |
| Zdroj: | Frontiers in Neurology (April 2016), 7, ISSN: 1664-2295. DOI: 10.3389/fneur.2016.00049. Artikelnr.: 49 |
| Druh dokumentu: | Článek |
| Popis: | Purpose: To review the roles of the different vascular beds nourishing the inner retina [retinal ganglion cells (RGCs)] during normal development of the human eye, using our own tissue specimens to support our conclusions. Methods: An extensive search of the appropriate literature included PubMed, Google scholar, and numerous available textbooks. In addition, choroidal and retinal NADPH-diaphorase stained whole mount preparations were investigated. Results: The first critical interaction between vascular bed and RGC formation occurs in the sixth to eighth month of gestation leading to a massive reduction of RGCs mainly in the peripheral retina. The first 3 years of age are characterized by an intense growth of the eyeball to near adult size. In the adult eye, the influence of the choroid on inner retinal nutrition was determined by examining the peripheral retinal watershed zones in more detail. Conclusion: This delicately balanced situation of RGC nutrition is described in the different regions of the eye, and a new graphic presentation is introduced to combine morphological measurements and clinical visual field data. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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