Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma
| Autor: | Distler, Marius, Rückert, Felix, Hunger, Maximilian, Kersting, Stephan, Pilarsky, Christian, Saeger, Hans-Detlev, Grützmann, Robert |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Bauchspeicheldrüsenkrebs
Tumormarker Chirurgie Whipple'sche Operation pyloruserhaltende Pankreaskopfresektion TU Dresden Publikationsfonds Pancreatic cancer Tumor marker Surgery Whipple procedure Pylorus-preserving pancreatoduodenectomy (PPPD) Technical University Dresden Publication funds ddc:610 rvk:XH 7523 |
| Zdroj: | BMC Surgery 2013, 13:12, ISSN: 1471-2482 |
| Druh dokumentu: | Článek |
| Popis: | Background: Surgery remains the only curative option for the treatment of pancreatic adenocarcinoma (PDAC). The goal of this study was to investigate the clinical outcome and prognostic factors in patients after resection for ductal adenocarcinoma of the pancreatic head. Methods: The data from 195 patients who underwent pancreatic head resection for PDAC between 1993 and 2011 in our center were retrospectively analyzed. The prognostic factors for survival after operation were evaluated using multivariate analysis. Results: The head resection surgeries included 69.7% pylorus-preserving pancreatoduodenectomies (PPPD) and 30.3% standard Kausch-Whipple pancreatoduodenectomies (Whipple). The overall mortality after pancreatoduodenectomy (PD) was 4.1%, and the overall morbidity was 42%. The actuarial 3- and 5-year survival rates were 31.5% (95% CI, 25.04%-39.6%) and 11.86% (95% CI, 7.38%-19.0%), respectively. Univariate analyses demonstrated that elevated CEA (p = 0.002) and elevated CA 19–9 (p = 0.026) levels, tumor grade (p = 0.001) and hard texture of the pancreatic gland (p = 0.017) were significant predictors of a poor survival. However, only CEA >3 ng/ml (p |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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