| Autor: |
Obrenovitch, Tihomir P., Chazot, P.L., Godukhin, O.V. |
| Jazyk: |
angličtina |
| Rok vydání: |
2002 |
| Předmět: |
|
| Druh dokumentu: |
Článek |
| DOI: |
10.1016/S0304-3940(02)00046-0 |
| Popis: |
In the November issue (2001) of Neuroscience Letters, Holmin et al. (Neurosci. Lett. 314 (2001) 151) reported that the synthesis of the intermediate filament protein nestin was upregulated by potassium-induced depolarization in the rat cortex. In this letter, we provide supplementary evidence that repeated cortical spreading depression elicited by potassium induces a delayed upregulation of nestin. However, we argue against the authors' conclusion, Nestin expression was N-methyl-D-aspartate (NMDA)-receptor dependent since dizocilpine (MK-801) treatment abolished the response because spreading depression itself is very sensitive to NMDA-receptor block, and the drug treatment was initiated prior to potassium application to the cortex in Holmin et al.'s study. |
| Databáze: |
Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
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