The dietary flavonol quercetin ameliorates angiotensin II-induced redox signaling imbalance in a human unbilical vein endothelial cell model of endothelial dysfunction via ablation of p47phox expression

Autor:	Jones, Huw, Gordon, A., Magwensi, S.G., Naseem, K., Atkin, S.L., Courts, F.L.
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Endothelial cells NADPH oxidase Nitric oxide Quercetin Superoxide
Druh dokumentu:	Článek
DOI:	10.1002/mnfr.201500751
Popis:	Yes Quercetin is reported to reduce blood pressure in hypertensive but not normotensive humans, but the role of endothelial redox signaling in this phenomenon has not been assessed. This study investigated the effects of physiologically obtainable quercetin concentrations in a human primary cell model of endothelial dysfunction in order to elucidate the mechanism of action of its antihypertensive effects. Angiotensin II (100 nM, 8 h) induced dysfunction, characterized by suppressed nitric oxide availability (85 ± 4% p Innovate UK and Boots Pharmaceuticals
Databáze:	Networked Digital Library of Theses & Dissertations
Externí odkaz:	http://hdl.handle.net/10454/17790 Zobrazit plný text záznamu