Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder
| Autor: | Cao, Q., Howard, J.L., Crawford, Deborah E., James, S.L., Browne, D.L. |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Druh dokumentu: | Článek |
| DOI: | 10.1039/C8GC02036A |
| Popis: | Yes A study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m−3 day−1 in a mixer mill to 3395 kg m−3 day−1 in a twin screw extruder. D. L. B is grateful to the EPSRC for a First Grant (D. L. B. EP/P002951/1), CRD for a studentship award to J. L. H., Queen’s University Belfast for a Visiting Research Fellowship and the School of Chemistry at Cardiff University for generous support. S. L. J. is grateful to EPSRC for support (EP/L019655/1). |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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