Progressive development of aberrant smooth muscle cell phenotype in abdominal aortic aneurysm disease

Autor:	Riches-Suman, Kirsten, Clark, E., Helliwell, R.J., Angelini, T.G., Hemmings, K.E., Bailey, M.A., Bridge, K.I., Scott, D.J.A., Porter, K.E.
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Abdominal aortic aneurysm Human Porcine Smooth muscle cells Aging DNA damage Senescence In vitro
Druh dokumentu:	Článek
DOI:	10.1159/000484088
Popis:	Yes Abdominal aortic aneurysm (AAA) is a silent, progressive disease with high mortality and increasing prevalence with aging. Smooth muscle cell (SMC) dysfunction contributes to gradual dilatation and eventual rupture of the aorta. Here we studied phenotypic characteristics in SMC cultured from end-stage human AAA (5cm) and cells cultured from a porcine carotid artery (PCA) model of early and end-stage aneurysm. Human AAA-SMC presented a secretory phenotype and expressed elevated levels of differentiation marker miR-145 (2.2-fold, P Supported in part by a grant from the Leeds Teaching Hospitals Charitable Foundation (9R11/8002)
Databáze:	Networked Digital Library of Theses & Dissertations
Externí odkaz:	http://hdl.handle.net/10454/14364 Zobrazit plný text záznamu