Core (Polystyrene)−Shell [Poly(glycerol monomethacrylate)] Particles
| Autor: | Mckenzie, A., Hoskins, Richard, Swift, Thomas, Grant, Colin A., Rimmer, Stephen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Druh dokumentu: | Článek |
| DOI: | 10.1021/acsami.6b15004 |
| Popis: | Yes A set of water-swollen core−shell particles was synthesized by emulsion polymerization of a 1,3-dioxolane functional monomer in water. After removal of the 1,3- dioxolane group, the particles’ shells were shown to swell in aqueous media. Upon hydrolysis, the particles increased in size from around 70 to 100−130 nm. A bicinchoninic acid assay and ζ-potential measurements were used to investigate the adsorption of lysozyme, albumin, or fibrinogen. Each of the core−shell particles adsorbed significantly less protein than the noncoated core (polystyrene) particles. Differences were observed as both the amount of difunctional, cross-linking monomer and the amount of shell monomer in the feed were changed. The core−shell particles were shown to be resistant to protein adsorption, and the degree to which the three proteins adsorbed was dependent on the formulation of the shell. EPSRC and MRC |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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