In vivo mapping of vascular inflammation using the translocator protein tracer 18F-FEDAA1106
| Autor: | Cuhlmann, S., Gsell, W., Van der Heiden, K., Habib, J., Tremoleda, J.L., Khalil, M., Turkheimer, F., Meens, M.J., Kwak, B.R., Bird, Joseph, Davenport, A.P., Clark, J., Haskard, D., Krams, R., Jones, H., Evans, P.C. |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Druh dokumentu: | Článek |
| DOI: | 10.2310/7290.2014.00014 |
| Popis: | Yes Non-invasive imaging methods are required to monitor the inflammatory content of atherosclerotic plaques. FEDAA1106 (N-(5-fluoro-2-phenoxyphenyl)-N-(2-(2-fluoroethoxy)-5- methoxybenzyl) acetamide) is a selective ligand for TSPO-18kDa (also known as peripheral benzodiazepine receptor), which is expressed by activated macrophages. We compared 18F- FEDAA1106 and 18F-FDG (a marker of glucose metabolism) for PET imaging of vascular inflammation. This was tested using a murine model where focal inflammation was induced in the carotid artery via placement of a constrictive cuff. Immunostaining revealed CD68-positive cells (macrophages) at a disturbed flow site located downstream from the cuff. Dynamic PET imaging using 18F-FEDAA1106 or 18F-FDG was registered to anatomical data generated by CT/CT angiography. Standardized uptake values (SUV) were significantly increased at cuffed compared to contralateral arteries using either 18F-FEDAA1106 (p This study was funded by the British Heart Foundation and through a grant from the Swiss National Science Foundation (310030_143343/1 to B.R.K.) |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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