Design, production and characterisation of IGF-I analogues with increased gastric stability / by Katherine J. Bryant.

Autor:	Bryant, Katherine J. (Katherine Jane), 1962
Rok vydání:	1995
Předmět:	Somatomedin. Insulin Derivatives. Gastrointestinal hormones. Porcine somatotropin. Growth factors.
Popis:	Bibliography: leaves 112-140. xi, 141, [39] leaves, [8] leaves of plates : ill. ; 30 cm. Title page, contents and abstract only. The complete thesis in print form is available from the University Library. The aims of this thesis are to determine the initial cleavage sites of purified pepsin in long-R3-IGF-I and assess whether the resulting cleavages affect biological activity, to design and produce analogues of long-R3-IGF-I which contain amino acid substitutions, to characterise the resulting analogues for pepsin resistance and retention of biological activity and to assess the stability of the long-R3-IGF-I analogues under in vivo conditions using luminal stomach flushings. Thesis (Ph.D.)--University of Adelaide, Dept. of Biochemistry, 1996
Databáze:	Networked Digital Library of Theses & Dissertations
Externí odkaz:	http://hdl.handle.net/2440/19074 Zobrazit plný text záznamu