Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors

Autor: Arnold, Moriah R., Langelier, Marie-France, Gartrell, Jessica, Kirby, Ilsa T., Sanderson, Daniel J., Bejan, Daniel S., Šileikytė, Justina, Sundalam, Sunil K., Nagarajan, Shanthi, Marimuthu, Parthiban, Duell, Anna K., Shelat, Anang A., Pascal, John M., Cohen, Michael S.
Zdroj: In Cell Chemical Biology 15 December 2022 29(12):1694-1708
Databáze: ScienceDirect