Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Autor: Gorrie, George, Morrison, Ian, Duncan, Callum, Carod Artal, Javier, Williams, Timothy, Srinivasan, Venkataramanan, Radunovic, Aleksandar, Pinto, Ashwin, Hamdalla, Hisham, Roberts, Rhys, Garcia- Reitboeck, Pablo, Harrower, Timothy, Mamutse, Godwin, Crawley, Francesca, Galton, Clare, Dawson, Kenneth, Forbes, Raeburn, Hillier, Charles, McDermott, Christopher, Forbes, Deborah, Bozkurt, Hatice, Stavrou, Maria, Kearns, Patrick, Breen, David, Kurucu King, Hatice, Elliot, Elizabeth, Beswick, Emily, Williamson, Jill, Cucurachi, Paolo, McLennan, Lucy, Pal, Suvankar a, b, c, d, g, i, *, Chataway, Jeremy g, h, i, l, Swingler, Robert j, Macleod, Malcolm R c, i, Carragher, Neil O f, Hardingham, Giles d, Selvaraj, Bhuvaneish Thangaraj a, b, c, d, Smith, Colin a, c, Wong, Charis a, b, c, g, Newton, Judith a, b, c, i, Lyle, Dawn a, b, c, Stenson, Amy a, b, c, i, Dakin, Rachel S a, b, c, Ihenacho, Amarachi a, b, c, Colville, Shuna a, b, c, Mehta, Arpan R a, b, c, i, n, Stallard, Nigel k, Carpenter, James R g, i, Parker, Richard A e, i, Keerie, Catriona e, Weir, Christopher J e, g, i, Virgo, Bruce m, Morris, Stevie m, Waters, Nicola m, Gray, Beverley m, MacDonald, Donald m, MacDonald, Euan m, †, Parmar, Mahesh K B g, i, Chandran, Siddharthan a, b, c, d, g, i
Zdroj: In The Lancet Neurology November 2024 23(11):1097-1107
Databáze: ScienceDirect