Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure–activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors
Autor: | Imaizumi, Tomoyoshi, Shimada, Itsuro, Satake, Yoshiki, Yamaki, Susumu, Koike, Takanori, Nigawara, Takahiro, Kaneko, Osamu, Amano, Yasushi, Mori, Kenichi, Yamanaka, Yosuke, Nakayama, Ayako, Nishizono, Yoshihiro, Shimazaki, Masashi, Nagashima, Takeyuki, Kuramoto, Kazuyuki |
---|---|
Zdroj: | In Bioorganic & Medicinal Chemistry 15 January 2024 98 |
Databáze: | ScienceDirect |
Externí odkaz: |