Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors

Autor: Deng, Guanghui, Zhao, Baowei, Ma, Yingli, Xu, Qiongfeng, Wang, Hailong, Yang, Liuqing, Zhang, Qing, Guo, Taylor B., Zhang, Wei, Jiao, Yang, Cai, Xin, Zhang, Jinqiang, Liu, Houfu, Guan, Xiaoming, Lu, Hongtao, Xiang, Jianing, Elliott, John D., Lin, Xichen, Ren, Feng
Zdroj: In Bioorganic & Medicinal Chemistry 1 November 2013 21(21):6349-6358
Databáze: ScienceDirect