Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3- d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors

Autor: Zhang, Xin, Zhou, Xilin, Kisliuk, Roy L., Piraino, Jennifer, Cody, Vivian, Gangjee, Aleem
Zdroj: In Bioorganic & Medicinal Chemistry 2011 19(11):3585-3594
Databáze: ScienceDirect