Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology

Autor: Melancon, Bruce J., Wood, Michael R., Noetzel, Meredith J., Nance, Kellie D., Engelberg, Eileen M., Han, Changho, Lamsal, Atin, Chang, Sichen, Cho, Hyekyung P., Byers, Frank W., Bubser, Michael, Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Engers, Darren W., Wu, Dedong, Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Zdroj: In Bioorganic & Medicinal Chemistry Letters 1 June 2017 27(11):2296-2301
Databáze: ScienceDirect