Mitigation of reactive metabolite formation for a series of 3-amino-2-pyridone inhibitors of Bruton’s tyrosine kinase (BTK)

Autor: Lou, Yan, Lopez, Francisco, Jiang, Yongying, Han, Xiaochun, Brotherton, Chris, Billedeau, Roland, Gabriel, Steve, Gleason, Shelly, Goldstein, David M., Hilgenkamp, Ramona, Kocer, Buelent, Orzechowski, Lucja, Tan, Jenny, Wovkulich, Peter, Wen, Bo, Fry, David, Di Lello, Paola, Chen, Lucy, Zhang, Fang-jie, Fretland, Jennifer, Nangia, Anjali, Yang, Tian, Owens, Timothy D.
Zdroj: In Bioorganic & Medicinal Chemistry Letters 1 February 2017 27(3):632-635
Databáze: ScienceDirect