Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Autor:	Wood, Michael R., Noetzel, Meredith J., Poslusney, Michael S., Melancon, Bruce J., Tarr, James C., Lamsal, Atin, Chang, Sichen, Luscombe, Vincent B., Weiner, Rebecca L., Cho, Hyekyung P., Bubser, Michael, Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Engers, Darren W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Zdroj:	In Bioorganic & Medicinal Chemistry Letters 15 January 2017 27(2):171-175
Databáze:	ScienceDirect
Externí odkaz:	Zobrazit plný text záznamu Full Text from ScienceDirect