Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase

Autor: Hewawasam, Piyasena, Tu, Yong, Gao, Min, Hanumegowda, Umesh, Knipe, Jay, Lemm, Julie A., Parker, Dawn D., Rigat, Karen L., Roberts, Susan B., Meanwell, Nicholas A., Kadow, John F.
Zdroj: In Bioorganic & Medicinal Chemistry Letters 1 February 2016 26(3):936-940
Databáze: ScienceDirect