Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure–activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1

Autor: Sifferlen, Thierry, Boller, Amandine, Chardonneau, Audrey, Cottreel, Emmanuelle, Hoecker, Johannes, Aissaoui, Hamed, Williams, Jodi T., Brotschi, Christine, Heidmann, Bibia, Siegrist, Romain, Gatfield, John, Treiber, Alexander, Brisbare-Roch, Catherine, Jenck, Francois, Boss, Christoph
Zdroj: In Bioorganic & Medicinal Chemistry Letters 15 February 2014 24(4):1201-1208
Databáze: ScienceDirect
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