Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes

Autor: DeNinno, Michael P., Wright, Stephen W., Etienne, John B., Olson, Thanh V., Rocke, Benjamin N., Corbett, Jeffrey W., Kung, Daniel W., DiRico, Kenneth J., Andrews, Kim M., Millham, Michele L., Parker, Janice C., Esler, William, van Volkenburg, Maria, Boyer, David D., Houseknecht, Karen L., Doran, Shawn D.
Zdroj: In Bioorganic & Medicinal Chemistry Letters 1 September 2012 22(17):5721-5726
Databáze: ScienceDirect