Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X 7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535
| Autor: | Duplantier, Allen J., Dombroski, Mark A., Subramanyam, Chakrapani, Beaulieu, Aimee M., Chang, Shang-Poa, Gabel, Christopher A., Jordan, Crystal, Kalgutkar, Amit S., Kraus, Kenneth G., Labasi, Jeff M., Mussari, Christopher, Perregaux, David G., Shepard, Rick, Taylor, Timothy J., Trevena, Kristen A., Whitney-Pickett, Carrie, Yoon, Kwansik |
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| Zdroj: | In Bioorganic & Medicinal Chemistry Letters 2011 21(12):3708-3711 |
| Databáze: | ScienceDirect |
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