Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[( trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4- b]pyrazin-2(1 H)-one

Autor:	Hughes, Robert O., Walker, John K., Joseph Rogier, D., Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Jon Jacobsen, E., Cubbage, Jerry W., Fobian, Yvette M., Owen, Dafydd R., Freskos, John N., Molyneaux, John M., Brown, David L., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying
Zdroj:	In Bioorganic & Medicinal Chemistry Letters 2009 19(17):5209-5213
Databáze:	ScienceDirect
Externí odkaz:	Zobrazit plný text záznamu Full Text from ScienceDirect