Optimization of a series of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway

Autor: Chamberlain, Stanley D., Redman, Anikó M., Patnaik, Samarjit, Brickhouse, Keith, Chew, Yen-Chiat, Deanda, Felix, Gerding, Roseanne, Lei, Huangshu, Moorthy, Ganesh, Patrick, Mark, Stevens, Kirk L., Wilson, Joseph W., Brad Shotwell, J.
Zdroj: In Bioorganic & Medicinal Chemistry Letters 2009 19(2):373-377
Databáze: ScienceDirect