Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

Autor: Walker, Daniel P., Christopher Bi, F., Kalgutkar, Amit S., Bauman, Jonathan N., Zhao, Sabrina X., Soglia, John R., Aspnes, Gary E., Kung, Daniel W., Klug-McLeod, Jacquelyn, Zawistoski, Michael P., McGlynn, Molly A., Oliver, Robert, Dunn, Matthew, Li, Jian-Cheng, Richter, Daniel T., Cooper, Beth A., Kath, John C., Hulford, Catherine A., Autry, Christopher L., Luzzio, Michael J., Ung, Ethan J., Roberts, W. Gregory, Bonnette, Peter C., Buckbinder, Leonard, Mistry, Anil, Griffor, Matthew C., Han, Seungil, Guzman-Perez, Angel
Zdroj: In Bioorganic & Medicinal Chemistry Letters 1 December 2008 18(23):6071-6077
Databáze: ScienceDirect
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