10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3- d]pyridazine-1,9(2 H,6 H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants

Autor: Wiscount, Catherine M., Williams, Peter D., Tran, Lekhanh O., Embrey, Mark W., Fisher, Thorsten E., Sherman, Vanessa, Homnick, Carl F., Donnette Staas, D., Lyle, Terry A., Wai, John S., Vacca, Joseph P., Wang, ZiQiang, Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Miller, Michael D., Hazuda, Daria J., Day, Alysha M., Gabryelski, Lori J., Ecto, Linda T., Schleif, William A., DiStefano, Daniel J., Kochansky, Christopher J., Reza Anari, M.
Zdroj: In Bioorganic & Medicinal Chemistry Letters 2008 18(16):4581-4583
Databáze: ScienceDirect