A large HIV gp41 construct with trimer-of-hairpins structure exhibits V2E mutation-dominant attenuation of vesicle fusion and helicity very similar to V2E attenuation of HIV fusion and infection and supports: (1) hairpin stabilization of membrane apposition with larger distance for V2E; and (2) V2E dominance by an antiparallel β sheet with interleaved fusion peptide strands from two gp41 trimers
| Autor: | Rokonujjaman, Md, Sahyouni, Abdulrazak, Wolfe, Robert, Jia, Lihui, Ghosh, Ujjayini, Weliky, David P. |
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| Zdroj: | In Biophysical Chemistry February 2023 293 |
| Databáze: | ScienceDirect |
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