Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors
| Autor: | Zhao, Jiaxing, Mao, Qing, Lin, Fengwei, Zhang, Bing, Sun, Ming, Zhang, Tingjian, Wang, Shaojie |
|---|---|
| Zdroj: | In European Journal of Medicinal Chemistry 5 February 2022 229 |
| Databáze: | ScienceDirect |
| Externí odkaz: |
|
Full Text from ScienceDirect