Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease

Autor: Takata, Kazuyuki, Amamiya, Takahide, Mizoguchi, Hiroaki, Kawanishi, Shohei, Kuroda, Eriko, Kitamura, Risa, Ito, Aina, Saito, Yuki, Tawa, Manami, Nagasawa, Tomofumi, Okamoto, Haruka, Sugino, Yuko, Takegami, Shigehiko, Kitade, Tatsuya, Toda, Yuki, Kem, William R., Kitamura, Yoshihisa, Shimohama, Shun, Ashihara, Eishi
Zdroj: In Neurobiology of Aging February 2018 62:197-209
Databáze: ScienceDirect
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