Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease
| Autor: | Sajan, Mini P., Hansen, Barbara C., Higgs, Margaret G., Kahn, C. Ron, Braun, Ursula, Leitges, Michael, Park, Collin R., Diamond, David M., Farese, Robert V. |
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| Zdroj: | In Neurobiology of Aging January 2018 61:225-237 |
| Databáze: | ScienceDirect |
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