Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth

Autor: Gustchina, Elena, Louis, John M., Frisch, Christian, Ylera, Francisco, Lechner, Annette, Bewley, Carole A., Clore, G. Marius
Zdroj: In Virology 2009 393(1):112-119
Databáze: ScienceDirect
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