N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a “chemical knock-out equivalent” to assess the impact of efflux transporters on oral drug absorption in the rat

Autor: Kalgutkar, Amit S. *, Frederick, Kosea S., Chupka, Jonathan, Feng, Bo, Kempshall, Sarah, Mireles, Rochelle J., Fenner, Katherine S., Troutman, Matthew D.
Zdroj: In Journal of Pharmaceutical Sciences December 2009 98(12):4914-4927
Databáze: ScienceDirect
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