Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency

Autor: Vahedi, Shahrooz, Chufan, Eduardo E., Ambudkar, Suresh V.
Zdroj: In Biochemical Pharmacology 1 November 2017 143:53-64
Databáze: ScienceDirect