Dose-limiting inhibition of acetylcholinesterase by ladostigil results from the rapid formation and fast hydrolysis of the drug–enzyme complex formed by its major metabolite, R-MCPAI

Autor: Moradov, Dorit, Finkin-Groner, Efrat, Bejar, Corina, Sunita, Priyashree, Schorer-Apelbaum, Donna, Barasch, Dinorah, Nemirovski, Alina, Cohen, Marganit, Weinstock, Marta
Zdroj: In Biochemical Pharmacology 15 March 2015 94(2):164-172
Databáze: ScienceDirect