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Diabetes mellitus is known to be a chronic metabolic disorder caused due to an impaired metabolism of glucose and other energy-providing molecules characterized by a slow progression of vascular and neuropathic complications. The present volume reviews the elucidation of several bioactive extracts from 25 potential medicinal plants (largely used in traditional medicine) and their mechanism of action in treatment of diabetes. These 25 herbs have been proved for its anti-diabetic potential using in vitro and in vivo model systems. Several strategies have been used in the management and treatment of diabetes. These strategies are targeted towards increasing endogenous insulin availability (sulfonylureas) enhancing insulin sensitivity and inhibiting?-glucosidase. Experimental evidences presented in core drug have shown and proven that each of these herbs possess bioactive compounds with anti-diabetic properties. In other words, this volume is a comprehensive compilation covering all aspects of Diabetes Management touching from topics like Definition and Etiology, Pathophysiology to adversities and toxicology, from pharmacological management to herbal drug delivery through Nanotechnology, from insights into the plant insulin to insights into the management of metabolic disorders in pharmacology. Hence, the information is presented in two parts. Diabetes I provide information on the wide range of basic components that are necessary for the management of Diabetes. Besides, the review of seven plants namely, Adhatoda vasica, Aegle marmelos, Andrographis paniculata, Allium sativum, Annona squamosa, Azadirachta indica and Carissa edulis, serves as a compilation of details in the isolation of pure compounds in relation to antidiabetic effects and their potential mode of action. In the second part i.e. Diabetes II, eighteen plants presented are Cinnamon, Coccinia indica, Eucalyptus globulus, Eugenia jambos, Ficus glomerata, Gymnema sylvestris, Ipomea batotos, Medicago sativa, Momordica charantia, Nelumbo nucifera, Nigella sativa, Pongamia pinnata, Swertia chirayita, Syzygium malaccense, Tinospora cordifolia, Trigonella foenum-graceum, Vinca rosea, Withania somnifera. Both the volumes have been presented in a manner that is simple and easy to understand where a balance between theory and practical inputs has been struck. The contributions are from far and wide including Canada, Ethiopia India, KSA, Malaysia, Mauritius, Nigeria, Pakistan, Romania, Spain, and USA. The volume is aimed at a wide range of audience of ethnobotanists, phytochemists, pharmacologists, pharmacists, pharmacognosists and other research scientists engaged in the search of new drugs from natural resources for Diabetes Mellitus treatment. |
