| Popis: |
Retinoids are valuable drugs in the dermatologic armamentarium, being employed in daily clinical practice. The text provides an in-depth update on the latest thinking on pharmacology, clinical use, side effects, and follow-up of retinoid therapy in dermatology; it also addresses topics related to retinoid use in special circumstances, such as vulnerable populations, concomitant surgery, and aesthetic procedures.CONTENTS: The background of retinoids • Mechanism of action of vitamin A • Mechanism of action of topical retinoids • Mechanism of action of isotretinoin • Mechanism of action of acitretin • Mechanism of action of bexarotene • Mechanism of action of alitretinoin • Effects of retinoids at the cellular level (differentiation, apoptosis, autophagy, cell cycle regulation, and senescence) • Effects of retinoids at the systemic level • New aspects of isotretinoin teratogenicity • Mucocutaneous side effects • Ophthalmologic side effects • Musculoskeletal side effects • Neurologic side effects • Psychiatric side effects • Gastrointestinal side effects • Endocrine and metabolic side effecs • Other systemic side effects: Cardiovascular, pulmonary, otolaryngorhinologic, genitourinary, renal, and immunologic • Retinoids in acne • Retinoids in hidradenitis suppurativa/acne inversa • Retinoids in rosacea • Retinoids in hair disorders • Retinoids in psoriasis • Retinoids in keratinization disorders • Retinoids in antiaging therapy • Retinoids in other skin diseases • Retinoids in lymphoma • Retinoids in cutaneous chemoprophylaxis • Guide to good clinical practice for vulnerable populations (infancy, childhood, fertile period, elderly) • Retinoids and concomitant surgery • Retinoids and concomitant aesthetic procedures • Laboratory and clinical follow-up • Teratogenicity and registry programs • Management of vitamin A and retinoid side effects • Future and novel unexplored indications of retinoidsPublished in association with the Journal of Dermatological Treatment. |
