Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia: A Pilot Study
| Autor: | E. Iacob, S. C. Tadler, K. C. Light, H. R. Weeks, K. W. Smith, A. T. White, R. W. Hughen, T. A. VanHaitsma, L. A. Bushnell, A. R. Light |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Depression Research and Treatment, Vol 2014 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2090-1321 2090-133X |
| DOI: | 10.1155/2014/582380 |
| Popis: | Objective. To evaluate leukocyte gene expression for 9 selected genes (mRNAs) as biological markers in patients with medication refractory depression before and after treatment with ECT or isoflurane anesthesia (ISO). Methods. In a substudy of a nonrandomized open-label trial comparing effects of ECT to ISO therapy, blood samples were obtained before and after treatment from 22 patients with refractory depression, and leukocyte mRNA was assessed by quantitative PCR. Patients’ mRNAs were also compared to 17 healthy controls. Results. Relative to controls, patients before treatment showed significantly higher IL10 and DBI and lower ADRA2A and ASIC3 mRNA (P |
| Databáze: | Directory of Open Access Journals |
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