Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity

Autor: Anne Witczak, Bernard Banaigs, Anne-Marie Genevière, Chantal Barthomeuf, Laurent Soulère, Christophe Menniti, Annabel Simon-Levert
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Marine Drugs, Vol 8, Iss 2, Pp 347-358 (2010)
Druh dokumentu: article
ISSN: 1660-3397
DOI: 10.3390/md8020347
Popis: Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.
Databáze: Directory of Open Access Journals