Switching iron sucrose to ferric carboxymaltose associates to better control of iron status in hemodialysis patients

Autor: Jesse M. G. Hofman, Michele F. Eisenga, Adry Diepenbroek, Ilja M. Nolte, Bastiaan van Dam, Ralf Westerhuis, Stephan J. L. Bakker, Casper F. M. Franssen, Carlo A. J. M. Gaillard
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Nephrology, Vol 19, Iss 1, Pp 1-8 (2018)
Druh dokumentu: article
ISSN: 1471-2369
DOI: 10.1186/s12882-018-1045-8
Popis: Abstract Background Although the efficacy of iron sucrose (IS) and ferric carboxymaltose (FCM) in treating anemia in hemodialysis (HD) patients has been studied individually, a comparison of these two intravenous iron formulations has not yet been performed in HD patients. Methods We performed a retrospective audit on records of 221 stable HD patients from different HD centers in the Netherlands, who were switched from IS to FCM on a 1:1 ratio. To assess the effect of the switch on iron status parameters, data from 3 time points before and 3 time points after the switch were analyzed using linear mixed effects models. Subanalyses were done in 2 subgroups of patients anemic or iron deficient at baseline. Results Hemoglobin increased in all groups (anemic [1.4 g/dL, P
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