Low-Level Laser Therapy to the Major Salivary Glands Increases Salivary Flow and MUC5B Protein Secretion in Diabetic Patients with Hyposalivation: A Preliminary Study
| Autor: | Awaludin Wibawa, Jeerus Sucharitakul, Rungthip Dansirikul, Pagaporn P. Pisarnturakit, Patita Bhuridej, Pratanporn Arirachakaran |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Makara Journal of Health Research, Vol 22, Iss 1, Pp 14-21 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2356-3664 2356-3656 |
| DOI: | 10.7454/msk.v22i1.8547 |
| Popis: | Background: To investigate the effect of low-level laser therapy to salivary gland function in diabetic patients with hyposalivation. Methods: Twelve diabetic patients were recruited. A 940-nm indium-gallium-arsenide-phosphide low-power semiconductor diode laser was used to stimulate the major salivary glands with an irradiation time of 40 s; this was done three times a week for 2 consecutive weeks. Patients were given questionnaires related to dry mouth symptoms. Salivary flow rates, questionnaire responses as well as MUC7, MUC5B and histatin 5 protein salivary concentrations were assessed at the first and sixth visits after laser therapy as well at the 6-week follow-up visit. Results: The unstimulated salivary flow rate and MUC5B concentration at the follow-up visit significantly increased (p < 0.01). Histatin 5 concentration significantly decreased at the follow-up visit compared with that at the first visit (p < 0.05). The mean dry mouth score revealed a significant decrease in dry mouth symptoms at the sixth visit and follow-up visit compared with those at the first visit (p < 0.001). The positive correlation between dry mouth score and flow rate was the strongest at the sixth visit (rs = 0.549). Conclusions: Low-level laser therapy increased the salivary flow rate and decreased dry mouth symptoms in diabetic patients. |
| Databáze: | Directory of Open Access Journals |
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