Diagnosis and Monitoring of Neuronal Lesion in Severe Brain Injury
| Autor: | M. A. Moldavanov, V. Ye. Klimenko, A. V. Poleshchuk, V. B. Shumatov, N. A. Andreyeva, D. N. Kirilin |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Общая реаниматология, Vol 6, Iss 1 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1813-9779 2411-7110 |
| DOI: | 10.15360/1813-9779-2010-1-17 |
| Popis: | Objective: to search for an accessible, valid, and easy-to-use method for the diagnosis and monitoring of a neuronal lesion in severe brain injury (SBI). Subjects and methods. Thirty-three patients aged 18—55 years with isolated SBI (the Glasgow coma scores for admission consciousness were 6±2) were examined; the serum content of neuron-specific protein S-100B was further analyzed. Results and discussion. The cell damage marker concentration was substantially increased in the acute period of brain injury. When the pathological process followed a favorable course, S-100B was considerably decreased just on day 2 of the disease. When the changes were negative, S-100B concentrations remained virtually unchanged or even increased, which was indicative of secondary brain reperfusion/ischemic lesions. The mean baseline marker level varied with the type of brain injury diagnosed by computed tomography; the highest figures being noted in the groups where significant brain tissue lesion was detected. Key words: severe brain injury, prognosis, S-100B protein. |
| Databáze: | Directory of Open Access Journals |
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