Associated Features with Non-Sentinel Lymph Node Involvement in Early Stage Breast Cancer Patients who Have Positive Macrometastatic Sentinel Lymph Node

Autor: Hakan Ataş, Buket Altun Özdemir, Ebru Menekşe, Sabri Özden, Yunus Nadi Yüksek, Gül Dağlar
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: European Journal of Breast Health, Vol 16, Iss 3, Pp 192-197 (2020)
Druh dokumentu: article
ISSN: 2587-0831
DOI: 10.5152/ejbh.2020.5332
Popis: Objective:The main goal of this study is to determine the clinico-pathological factors that correlate non-sentinel lymph nodes (LNs) involvement in clinically node negative breast cancer (BC) patients with positive macrometastatic sentinel lymph node (SLN) in order to derive future evidence to define a subgroup where completion axillary lymph node dissection (cALND) might not be recommended.Materials and Methods: Total 289 SLN biopsies were performed in clinically node negative BC patients between March 2014 and April 2017. Seventy patients who performed cALND due to positive macrometastatic SLN were retrospectively selected and classified into two groups, according to non-SLN involvement (NSLNI). Clinico-pathological features of patients were examined computerized and documentary archives.Results: Extracapsular extension (ECE) of SLN, number of harvested SLNs, metastatic rate of SLNs, absence of ductal carcinoma in situ (DCIS) and presence of multilocalization were significantly associated with the likelihood of non-SLN involvement after univariate analysis (p
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