Global proteomic profiling of multiple organs of cats (Felis catus) and proteome-transcriptome correlation during acute Toxoplasma gondii infection

Autor:	Lan-Bi Nie, Wei Cong, Jun-Jun He, Wen-Bin Zheng, Xing-Quan Zhu
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Toxoplasma gondii Proteomics Transcriptomics Cat mRNA-protein correlation Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Zdroj:	Infectious Diseases of Poverty, Vol 11, Iss 1, Pp 1-16 (2022)
Druh dokumentu:	article
ISSN:	2049-9957
DOI:	10.1186/s40249-022-01022-7
Popis:	Abstract Background Toxoplasma gondii is a protozoan parasite which can infect almost all warm-blooded animals and humans. Understanding the differential expression of proteins and transcripts associated with T. gondii infection in its definitive host (cat) may improve our knowledge of how the parasite manipulates the molecular microenvironment of its definitive host. The aim of this study was to explore the global proteomic alterations in the major organs of cats during acute T. gondii infection. Methods iTRAQ-based quantitative proteomic profiling was performed on six organs (brain, liver, lung, spleen, heart and small intestine) of cats on day 7 post-infection by cysts of T. gondii PRU strain (Genotype II). Mascot software was used to conduct the student’s t-test. Proteins with P values 1.2 or
Databáze:	Directory of Open Access Journals
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