| Autor: |
Giovanni Peretto, Andrea Villatore, Stefania Rizzo, Antonio Esposito, Giacomo De Luca, Anna Palmisano, Davide Vignale, Alberto Maria Cappelletti, Moreno Tresoldi, Corrado Campochiaro, Silvia Sartorelli, Marco Ripa, Monica De Gaspari, Elena Busnardo, Paola Ferro, Maria Grazia Calabrò, Evgeny Fominskiy, Fabrizio Monaco, Giulio Cavalli, Luigi Gianolli, Francesco De Cobelli, Alberto Margonato, Lorenzo Dagna, Mara Scandroglio, Paolo Guido Camici, Patrizio Mazzone, Paolo Della Bella, Cristina Basso, Simone Sala |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of Clinical Medicine, Vol 10, Iss 9, p 1974 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2077-0383 |
| DOI: |
10.3390/jcm10091974 |
| Popis: |
Background. Myocarditis lacks systematic characterization in COVID-19 patients. Methods. We enrolled consecutive patients with newly diagnosed myocarditis in the context of COVID-19 infection. Diagnostic and treatment strategies were driven by a dedicated multidisciplinary disease unit for myocarditis. Multimodal outcomes were assessed during prospective follow-up. Results. Seven consecutive patients (57% males, age 51 ± 9 y) with acute COVID-19 infection received a de novo diagnosis of myocarditis. Endomyocardial biopsy was of choice in hemodynamically unstable patients (n = 4, mean left ventricular ejection fraction (LVEF) 25 ± 9%), whereas cardiac magnetic resonance constituted the first exam in stable patients (n = 3, mean LVEF 48 ± 10%). Polymerase chain reaction (PCR) analysis revealed an intra-myocardial SARS-CoV-2 genome in one of the six cases undergoing biopsy: in the remaining patients, myocarditis was either due to other viruses (n = 2) or virus-negative (n = 3). Hemodynamic support was needed for four unstable patients (57%), whereas a cardiac device implant was chosen in two of four cases showing ventricular arrhythmias. Medical treatment included immunosuppression (43%) and biological therapy (29%). By the 6-month median follow-up, no patient died or experienced malignant arrhythmias. However, two cases (29%) were screened for heart transplantation. Conclusions. Myocarditis associated with acute COVID-19 infection is a spectrum of clinical manifestations and underlying etiologies. A multidisciplinary approach is the cornerstone for tailored management. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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